Metabolito de la l-leucina, uno de los aminoácidos de cadena ramificada. La literatura lo asocia a la síntesis de proteína muscular, a la reducción de la degradación proteica por la vía ubiquitina-proteasoma y a la recuperación tras el ejercicio. Los estudios de seguridad citados evalúan consumos de 3 a 6 g diarios durante varios meses sin efectos secundarios reportados.
Balancing muscle hypertrophy and atrophy
HOFFMAN, E.P.; NADER, G.A.
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training
NISSEN, S.
Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+ yrs: a randomized, double-blind pilot trial
STOUT, J.R.; SMITH-RYAN, A.E.; FUKUDA, D.H.; KENDALL, K.L.; MOON, J.R.; HOFFMAN, J.R.; WILSON, J.M.; OLIVER, J.S.; MUSTAD, V.A.
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review
WILSON, G.J.; WILSON, J.M.; MANNINEN, A.H.
The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study
WILSON, J.M.; LOWERY, R.P.; JOY, J.M.; ANDERSEN, J.C.; WILSON, S.M.; STOUT, J.R.; DUNCAN, N.; FULLER, J.C.; BAIER, S.M.; NAIMO, M.A.; RATHMACHER, J.
β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men
WILSON, J.M.; FITSCHEN, P.J.; CAMPBELL, B.; WILSON, G.J.; ZANCHI, N.; TAYLOR, L.; WILBORN, C.; KALMAN, D.S.; STOUT, J.R.; HOFFMAN, J.R.; ZIEGENFUSS, T.N.; LOPEZ, H.L.; KREIDER, R.B.; SMITH-RYAN, A.E.; ANTONIO, J.
β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats
HAO, Y.; JACKSON, J.R.; WANG, Y.; EDENS, N.; PEREIRA, S.L.; ALWAY, S.E.
El β-hidroxi-β-metilbutirato (HMB) como suplemento nutricional (I): metabolismo y toxicidad. Nutrición Hospitalaria, 2015, 31(2), 590-596
MANJARREZ-MONTES-DE-OCA, R.; TORRES-VACA, M.; GONZÁLEZ-GALLEGO, J.; ALVEAR-ORDENES, I.
Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats
LYNCH, C.J.; HUTSON, S.M.; PATSON, B.J.; VAVAL, A.; VARY, T.C.
Kinetics of human growth hormone during submaximal exercise
LASSARRE, C.; GIRARD, F.; DURAND, J.; RAYNAUD, J.
